As a director and producer, Nathalia's work includes noiselab.tv (a series of online videos made in collaboration with a cult Mexican record label of the same name), music videos and adverts. In addition to developing online platforms and content, she has always worked in close collaboration with the music world, both as a consultant and music selector.

In 2012 she debuted as an actress in Carlos Reygadas' "Post Tenebras Lux", a film which won the award for best director (Palme d'Or) at the Cannes Film Festival that same year. Her most recent projects include  "Avenida Progreso" by Mauricio Guillén, "Interno" by Griffin Marcus and "How to disappear completely" by Antonio Macarro.